News and Views
Nature Structural & Molecular Biology 16, 235 - 236 (2009)
doi:10.1038/nsmb0309-235
Visualizing the twists and turns of a molecular chaperone
Len Neckers1, Shinji Tsutsumi1 & Mehdi Mollapour1
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Len Neckers, Shinji Tsutsumi and Mehdi Mollapour are in the Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, 9000 Rockville Pike, Bethesda, Maryland 20892, USA.
e-mail: len@helix.nih.gov
Abstract
Intermediate conformations of the Hsp90 ATPase cycle have been identified in solution by fluorescence resonance energy transfer, and the impact of nucleotides and of modulatory cochaperones has been visualized in real time.
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