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Nature Structural & Molecular Biology 16, 1121 - 1122 (2009)
doi:10.1038/nsmb1109-1121

Glycan terminator

James C Paulson1 & Christoph Rademacher1

  1. James C. Paulson and Christoph Rademacher are in the Departments of Chemical Physiology and Molecular Biology, The Scripps Research Institute, La Jolla, California, USA.

Correspondence to: James C Paulson1 e-mail: jpaulson@scripps.edu


Influenza virus binding to host cells and neutrophil trafficking to sites of inflammation are diverse aspects of biology mediated by receptor recognition of sialic acids that terminate glycans on cell surface glycoproteins and glycolipids. The first crystal structure of a mammalian sialyltransferase provides insights into the biosynthesis of the rich spectrum of sialic acid–containing glycans in the mammalian glycome.

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