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Nature Structural & Molecular Biology 16, 13–15 (1 January 2009) | doi:10.1038/nsmb0109-13

Alternative splicing: regulation without regulators

Brenton R Graveley

The field of alternative splicing is moving forward at a breathtaking pace. Only a little more than 10 years ago, it was thought that most human genes encoded only a single mRNA isoform.