Access
To read this article in full you may need to log in, make a payment or gain access through a site license (see right).
Article
Nature Structural & Molecular Biology 16, 23–29 (1 January 2009) | doi:10.1038/nsmb.1533
miR-29 miRNAs activate p53 by targeting p85|[alpha]| and CDC42
&
Abstract
The tumor suppressor p53 is central to many cellular stress responses. Although numerous protein factors that control p53 have been identified, the role of microRNAs (miRNAs) in regulating p53 remains unexplored. In a screen for miRNAs that modulate p53 activity, we find that miR-29 family members (miR-29a, miR-29b and miR-29c) upregulate p53 levels and induce apoptosis in a p53-dependent manner. We further find that miR-29 family members directly suppress p85α (the regulatory subunit of PI3 kinase) and CDC42 (a Rho family GTPase), both of which negatively regulate p53. Our findings provide new insights into the role of miRNAs in the p53 pathway.
To read this article in full you may need to log in, make a payment or gain access through a site license (see right).
