News and Views
Nature Structural & Molecular Biology 16, 9 - 10 (2009)
doi:10.1038/nsmb0109-9
RNA stability: is it the endo' the world as we know it?
Jeffrey Wilusz1
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Jeffrey Wilusz is in the Department of Microbiology Immunology and Pathology, Colorado State University, Fort Collins, Colorado 80523-1682, USA.
e-mail: jeffrey.wilusz@colostate.edu
Abstract
Endonucleases have generally not been considered among the major factors in well-studied mRNA-decay and quality-control pathways in mammals and yeast. However, two important players in these pathways, the exosome and SMG6, have now been shown to contain functionally significant endonucleolytic activities.
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