News and Views
Nature Structural & Molecular Biology 16, 13 - 15 (2009)
doi:10.1038/nsmb0109-13
Alternative splicing: regulation without regulators
Brenton R Graveley1
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Brenton R. Graveley is in the Department of Genetics and Developmental Biology, University of Connecticut Stem Cell Institute, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, Connecticut 06030-3301, USA.
e-mail: graveley@neuron.uchc.edu
Abstract
Alternative splicing is typically thought to be controlled by RNA binding proteins that modulate the activity of the spliceosome. A new study not only demonstrates that alternative splicing can be regulated without the involvement of auxiliary splicing factors, but also provides mechanistic insight into how this can occur.
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