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Nature Structural & Molecular Biology 16, 13 - 15 (2009)
doi:10.1038/nsmb0109-13

Alternative splicing: regulation without regulators

Brenton R Graveley1

  1. Brenton R. Graveley is in the Department of Genetics and Developmental Biology, University of Connecticut Stem Cell Institute, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, Connecticut 06030-3301, USA.
    e-mail: graveley@neuron.uchc.edu


Alternative splicing is typically thought to be controlled by RNA binding proteins that modulate the activity of the spliceosome. A new study not only demonstrates that alternative splicing can be regulated without the involvement of auxiliary splicing factors, but also provides mechanistic insight into how this can occur.

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