News and Views
Nature Structural & Molecular Biology 16, 11 - 13 (2009)
doi:10.1038/nsmb0109-11
Chromodomain-mediated spreading on active genes
Alison M Hosey1 & Marjorie Brand1
-
Alison M. Hosey and Marjorie Brand are at the The Sprott Center for Stem Cell Research, Regenerative Medicine Program, Ottawa Health Research Institute, 501 Smyth Road, Ottawa ON K1H 8L6, Canada.
e-mail: mbrand@ohri.ca
Abstract
The formation of heterochromatin involves spreading of repressor proteins along large chromosomal domains. A new study reveals that the concept of spreading also holds true for establishing domains of active chromatin. More specifically, spreading of the Drosophila melanogaster male-specific lethal (MSL) activator complex, which is required for dosage compensation on the X chromosome, involves interaction between the MSL3 chromodomain and histone H3 methylated at lysine 36.
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
NEWS AND VIEWS
Hit and run: X marks the spot!Nature Structural & Molecular Biology News and Views (01 Aug 2009)
RESEARCH
The MSL3 chromodomain directs a key targeting step for dosage compensation of the Drosophila melanogaster X chromosomeNature Structural & Molecular Biology Article (01 Dec 2008)
Drosophila MSL complex globally acetylates H4K16 on the male X chromosome for dosage compensationNature Structural & Molecular Biology Article (01 Aug 2009)
The roX genes encode redundant male-specific lethal transcripts required for targeting of the MSL complexThe EMBO Journal Article (01 Mar 2002)
See all 5 matches for Research
