1. Lubos Cipak, Mario Spirek and Juraj Gregan are in the Max F. Perutz Laboratories, Department of Chromosome Biology, University of Vienna, Dr. Bohr-Gasse 1, 1030 Vienna, Austria. e-mail: juraj.gregan@univie.ac.at

Abstract

Cohesin is a large ring-shaped protein complex that mediates cohesion between sister chromatids. New experiments show that the sister chromatids of a minichromosome are entrapped by monomeric cohesin rings, thus excluding the possibility that sister chromatid cohesion is mediated by nontopological interactions between cohesin complexes.

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