1. Graham A. Bentley is at the Institut Pasteur, Unité d'Immunologie Structurale, Centre National de la Recherche Scientifique URA2185, F-75724 Paris Cedex 15, France. e-mail: bentley@pasteur.fr
2. Benoît Gamain is at the Institut Pasteur, Unité de Biologie des Interactions Hôte-Parasite, Centre National de la Recherche Scientifique URA2581, F-75724 Paris Cedex 15, France. e-mail: bgamain@pasteur.fr

Abstract

The crystal structure of the CSA-binding Duffy-binding-like domain DBL3x of the VAR2CSA-encoded PfEMP1 adhesin has been solved in the free state and complexed with CSA oligosaccharides, shedding light on the major host-parasite interaction in pregnancy-associated malaria.

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