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Nature Structural & Molecular Biology 15, 893 - 895 (2008)
doi:10.1038/nsmb0908-893
Insights into PPAR
from structures with endogenous and covalently bound ligands
Kendall W Nettles1
- Kendall W. Nettles is in the Department of Cancer Biology, The Scripps Research Institute, Jupiter, Florida 33458, USA. e-mail: knettles@scripps.edu
Abstract
Peroxisome proliferator–activated receptor-
(PPAR) is a ligand-regulated transcription factor with crucial roles in carbohydrate and lipid metabolism and adipogenesis, but the structural details of the binding and activation by endogenous ligands are not known. Two recent studies reveal how oxidized and nitrated fatty acids uniquely bind and activate PPAR.
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