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Brief Communication
Nature Structural & Molecular Biology 15, 865–867 (1 August 2008) | doi:10.1038/nsmb.1447
Molecular recognition of nitrated fatty acids by PPAR|[gamma]|
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Abstract
Peroxisome proliferator activated receptor-γ (PPARγ) regulates metabolic homeostasis and adipocyte differentiation, and it is activated by oxidized and nitrated fatty acids. Here we report the crystal structure of the PPARγ ligand binding domain bound to nitrated linoleic acid, a potent endogenous ligand of PPARγ.
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