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A splicing regulator promotes transcriptional elongation

Nature Structural & Molecular Biology volume 15, pages 779–781 (2008)Cite this article

A new study reveals that the serine/arginine-rich splicing factor SC35 is necessary to promote RNA polymerase II elongation in a subset of genes, confirming a bidirectional coupling between transcription and splicing.

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Figure 1: An example of bidirectional coupling: a splicing factor regulates transcription, which in turn regulates alternative splicing.

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Authors and Affiliations

  1. Juan Pablo Fededa and Alberto R. Kornblihtt are at the Laboratorio de Fisiología y Biología Molecular, IFIByNE-CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina. ark@fbmc.fcen.uba.ar,

    Juan Pablo Fededa & Alberto R Kornblihtt

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  1. Juan Pablo Fededa
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  2. Alberto R Kornblihtt
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Fededa, J., Kornblihtt, A. A splicing regulator promotes transcriptional elongation. Nat Struct Mol Biol 15, 779–781 (2008). https://doi.org/10.1038/nsmb0808-779

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