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Nature Structural & Molecular Biology 15, 781 - 783 (2008)
doi:10.1038/nsmb0808-781
The chloride channel's appendix
Joseph A Mindell1
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Joseph A. Mindell is in the Membrane Transport Biophysics Unit, Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 35 Convent Drive, Building 35, MSC 3701, Bethesda, Maryland 20892.
e-mail: mindellj@ninds.nih.gov
Abstract
All CLC proteins transport Cl- across membranes. However, the family includes both Cl- channels and Cl-/H+ antiporters, proteins once thought to operate by dramatically different mechanisms. An apparent evolutionary relic, a proton-transport apparatus in a CLC channel, reveals deep intertwinings between channel and transporter mechanisms.
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