News and Views
Nature Structural & Molecular Biology 15, 775 - 776 (2008)
doi:10.1038/nsmb0808-775
Terminating transcription in yeast: whether to be a 'nerd' or a 'rat'
Ana G Rondon1, Hannah E Mischo1 & Nick J Proudfoot1
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Ana G. Rondon, Hannah E. Mischo and Nick J. Proudfoot are at the Sir William Dunn School of Pathology, University of Oxford, South Parks Rd, Oxford OX1 3RE, UK.
e-mail: nicholas.proudfoot@path.ox.ac.uk
Abstract
Transcriptional termination by RNA polymerase II in yeast occurs by two different pathways: stable or cryptic unstable transcripts use the Nrd1 complex, whereas mRNA uses 3' cleavage and polyadenylation factors together with Rat1 exonuclease. How RNA polymerase II selects which pathway to use is discussed.
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