Access
To read this article in full you may need to log in, make a payment or gain access through a site license (see right).
Brief Communication
Nature Structural & Molecular Biology 15, 761–763 (1 July 2008) | doi:10.1038/nsmb.1453
A second binding site for double-stranded RNA in TLR3 and consequences for interferon activation
&
Abstract
We show that substrate specificity of Toll-like receptor 3 (TLR3) is due to the presence of two binding sites in the ectodomain, separated by 50 |[Aring]|. This corresponds to two turns of a double-stranded RNA duplex, allowing differentiation between nucleic acids in the A- or B-type conformation. We propose that there are different arrangements of TLR3 ectodomains along the double-stranded RNA that could modulate the strength of the interferon response.
To read this article in full you may need to log in, make a payment or gain access through a site license (see right).
