Brief Communication abstract
Nature Structural & Molecular Biology 15, 761 - 763 (2008)
Published online: 22 June 2008 | doi:10.1038/nsmb.1453
A second binding site for double-stranded RNA in TLR3 and consequences for interferon activation
Nina Pirher1,
Karolina Ivi
ak1,
Jelka Pohar1,
Mojca Benina1
&
Roman Jerala1,2
Abstract
We show that substrate specificity of Toll-like receptor 3 (TLR3) is due to the presence of two binding sites in the ectodomain, separated by 50 Å. This corresponds to two turns of a double-stranded RNA duplex, allowing differentiation between nucleic acids in the A- or B-type conformation. We propose that there are different arrangements of TLR3 ectodomains along the double-stranded RNA that could modulate the strength of the interferon response.
- Department of Biotechnology, National Institute of Chemistry, Hajdrihova 19, 1000 Ljubljana, Slovenia.
- Faculty of Chemistry and Chemical Technology, University of Ljubljana, 1000 Ljubljana, Slovenia.
Correspondence to: Roman Jerala1,2 e-mail: roman.jerala@ki.si
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
NEWS AND VIEWS
Toll signaling: the TIReless quest for specificityNature Immunology News and Views (01 Feb 2003)
RESEARCH
TICAM-1, an adaptor molecule that participates in Toll-like receptor 3?mediated interferon-β inductionNature Immunology Article (01 Feb 2003)
Sequence- and target-independent angiogenesis suppression by siRNA via TLR3Nature Article (03 Apr 2008)
See all 5 matches for Research
