Brief Communication abstract
Nature Structural & Molecular Biology 15, 761 - 763 (2008)
Published online: 22 June 2008 | doi:10.1038/nsmb.1453
A second binding site for double-stranded RNA in TLR3 and consequences for interferon activation
Nina Pirher1,
Karolina Ivi
ak1,
Jelka Pohar1,
Mojca Benina1
&
Roman Jerala1,2
Abstract
We show that substrate specificity of Toll-like receptor 3 (TLR3) is due to the presence of two binding sites in the ectodomain, separated by 50 Å. This corresponds to two turns of a double-stranded RNA duplex, allowing differentiation between nucleic acids in the A- or B-type conformation. We propose that there are different arrangements of TLR3 ectodomains along the double-stranded RNA that could modulate the strength of the interferon response.
- Department of Biotechnology, National Institute of Chemistry, Hajdrihova 19, 1000 Ljubljana, Slovenia.
- Faculty of Chemistry and Chemical Technology, University of Ljubljana, 1000 Ljubljana, Slovenia.
Correspondence to: Roman Jerala1,2 e-mail: roman.jerala@ki.si
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