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Nature Structural & Molecular Biology 15, 544–546 (1 June 2008) | doi:10.1038/nsmb0608-544

Escaping amyloid fate

Blake E Roberts & James Shorter

Successful protein folding is key to all life. Yet, a significant portion of eukaryotic proteomes, perhaps even 30%, comprises proteins that are either entirely unfolded or contain large regions (|[sim]|40 amino acids or more) of intrinsic disorder.