1. Bryan M. Turner is at the Institute of Biomedical Research, University of Birmingham Medical School, Birmingham B15 2TT, UK.
   e-mail: b.m.turner@bham.ac.uk

Abstract

Methylated lysines are essential components of the network of histone modifications, or 'histone code', that regulates gene expression. Work on the methyltransferase Dot1 shows how modifications on different histones interact to modulate activity and how its catalytic mechanism is matched to its role in genome regulation.

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