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Nature Structural & Molecular Biology 15, 426–428 (1 May 2008) | doi:10.1038/nsmb0508-426
Modifications target spliceosome dynamics
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Abstract
The spliceosome is a remarkably dynamic RNA-protein (RNP) machine. As shown in Figure 1, the five small nuclear ribonucleoprotein particles (snRNPs) assemble onto an intron in a stepwise order in vitro.
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