1. Aaron J. Gottschalk, Ronald C. Conaway and Joan Weliky Conaway are at the Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA, and the Department of Biochemistry and Molecular Biology, Kansas University Medical Center, Kansas City, Kansas 66160, USA.
   e-mail: jlc@stowers-institute.org

Abstract

Since the discovery that actin and actin-related proteins (ARPs) reside in the nucleus as integral subunits of chromatin-modifying and chromatin-remodeling complexes, efforts to uncover their roles in chromatin regulation have met with limited success. In a new study, the previously mysterious helicase-SANT–associated (HSA) domain found in many chromatin regulatory complexes is shown to act as a module that directs recruitment and contributes to the action of actin and ARPs in chromatin regulation.

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