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Nature Structural & Molecular Biology 15, 428 - 430 (2008)
doi:10.1038/nsmb0508-428

The type II secretion arrowhead: the structure of GspI–GspJ–GspK

Katrina T Forest1

  1. Katrina T. Forest is at the Department of Bacteriology, University of Wisconsin-Madison, 1550 Linden Drive, Madison, Wisconsin 53706, USA.
    e-mail: forest@bact.wisc.edu


A heterotrimeric complex of minor pseudopilins from the type II secretion system has been identified and its crystal structure solved. Although each subunit shares the same overall alpha-beta fold as other characterized (pseudo)pilins, GspK has a unique large alpha-helical domain inserted between two canonical beta-strands. The structure constrains models for pseudopilus assembly.

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