1. Corina Maeder and Christine Guthrie are in the Department of Biochemistry and Biophysics, Genentech Hall N374, University of California San Francisco, 600 16th Street, San Francisco, California 94143-2200, USA.
   e-mail: guthrie@biochem.ucsf.edu.

Abstract

The splicing pathway is dominated by ATP-dependent RNA rearrangements promoted by DEAD-box helicases. Post-translational modifications have now been implicated in the regulation of two DEAD-box proteins that are required for catalytic activation of the spliceosome.

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