Table of contents
April 2008, Volume 15 No 4 pp331-423
About the coverEditorial
Cleaning up the EPA's act - p331
doi:10.1038/nsmb0408-331
On 12 March 2008, the US Environmental Protection Agency (EPA) released its latest standards for ozone emission, along with recommendations on how to update the Clean Air Act. This was followed by public outcry from medical associations, nonprofit organizations and media outlets.
Full Text - Cleaning up the EPA's act | PDF (207 KB) - Cleaning up the EPA's act
News and Views
INO80 meets a fork in the road - pp332 - 334
Kelly M Trujillo & Mary Ann Osley
doi:10.1038/nsmb0408-332
The INO80 chromatin-remodeling complex has roles in transcription, DNA repair and replication. By studying the role of Ino80 in DNA replication, a study now finds that the INO80 complex is essential for replication fork progression under conditions of replicative stress, stabilizes stalled forks and helps ensure proper restart.
Full Text - INO80 meets a fork in the road | PDF (279 KB) - INO80 meets a fork in the road
Think you know how miRNAs work? Think again. - pp334 - 336
Joel D Richter
doi:10.1038/nsmb0408-334
Two proposed mechanisms for how microRNAs (miRNAs) and their associated Argonaute proteins inhibit translation in mammals do not seem to operate in Drosophila melanogaster cells, suggesting that insights into important miRNA functions remain elusive. However, the interaction between Argonaute and the P-body factor GW182 may help in elucidating the biochemical basis of translational control by miRNAs.
Full Text - Think you know how miRNAs work? Think again. | PDF (270 KB) - Think you know how miRNAs work? Think again.
See also: Article by Eulalio et al.
Research Highlights
Research highlights - p337
doi:10.1038/nsmb0408-337
Full Text - Research highlights | PDF (125 KB) - Research highlights
Articles
The Ino80 chromatin-remodeling enzyme regulates replisome function and stability - pp338 - 345
Manolis Papamichos-Chronakis & Craig L Peterson
doi:10.1038/nsmb.1413
Abstract - | Full Text - The Ino80 chromatin-remodeling enzyme regulates replisome function and stability | PDF (566 KB) - The Ino80 chromatin-remodeling enzyme regulates replisome function and stability | Supplementary information
See also: News and Views by Trujillo & Ann Osley
GW182 interaction with Argonaute is essential for miRNA-mediated translational repression and mRNA decay - pp346 - 353
Ana Eulalio, Eric Huntzinger & Elisa Izaurralde
doi:10.1038/nsmb.1405
Abstract - | Full Text - GW182 interaction with Argonaute is essential for miRNA-mediated translational repression and mRNA decay | PDF (464 KB) - GW182 interaction with Argonaute is essential for miRNA-mediated translational repression and mRNA decay | Supplementary information
See also: News and Views by Richter
The regulatory activity of microRNA* species has substantial influence on microRNA and 3' UTR evolution - pp354 - 363
Katsutomo Okamura, Michael D Phillips, David M Tyler, Hong Duan, Yu-ting Chou & Eric C Lai
doi:10.1038/nsmb.1409
Abstract - | Full Text - The regulatory activity of microRNA* species has substantial influence on microRNA and 3' UTR evolution | PDF (1,119 KB) - The regulatory activity of microRNA* species has substantial influence on microRNA and 3' UTR evolution | Supplementary information
ATAC is a double histone acetyltransferase complex that stimulates nucleosome sliding - pp364 - 372
Tamaki Suganuma, José L Gutiérrez, Bing Li, Laurence Florens, Selene K Swanson, Michael P Washburn, Susan M Abmayr & Jerry L Workman
doi:10.1038/nsmb.1397
Abstract - | Full Text - ATAC is a double histone acetyltransferase complex that stimulates nucleosome sliding | PDF (619 KB) - ATAC is a double histone acetyltransferase complex that stimulates nucleosome sliding | Supplementary information
The retinitis pigmentosa 2 gene product is a GTPase-activating protein for Arf-like 3 - pp373 - 380
Stefan Veltel, Raphael Gasper, Elke Eisenacher & Alfred Wittinghofer
doi:10.1038/nsmb.1396
Abstract - | Full Text - The retinitis pigmentosa 2 gene product is a GTPase-activating protein for Arf-like 3 | PDF (704 KB) - The retinitis pigmentosa 2 gene product is a GTPase-activating protein for Arf-like 3 | Supplementary information
Roles of the Clr4 methyltransferase complex in nucleation, spreading and maintenance of heterochromatin - pp381 - 388
Ke Zhang, Kerstin Mosch, Wolfgang Fischle & Shiv I S Grewal
doi:10.1038/nsmb.1406
Abstract - | Full Text - Roles of the Clr4 methyltransferase complex in nucleation, spreading and maintenance of heterochromatin | PDF (675 KB) - Roles of the Clr4 methyltransferase complex in nucleation, spreading and maintenance of heterochromatin | Supplementary information
Pore-opening mechanism of the nicotinic acetylcholine receptor evinced by proton transfer - pp389 - 396
Gisela D Cymes & Claudio Grosman
doi:10.1038/nsmb.1407
Abstract - | Full Text - Pore-opening mechanism of the nicotinic acetylcholine receptor evinced by proton transfer | PDF (1,631 KB) - Pore-opening mechanism of the nicotinic acetylcholine receptor evinced by proton transfer | Supplementary information
Basis of altered RNA-binding specificity by PUF proteins revealed by crystal structures of yeast Puf4p - pp397 - 402
Matthew T Miller, Joshua J Higgin & Traci M Tanaka Hall
doi:10.1038/nsmb.1390
Abstract - | Full Text - Basis of altered RNA-binding specificity by PUF proteins revealed by crystal structures of yeast Puf4p | PDF (563 KB) - Basis of altered RNA-binding specificity by PUF proteins revealed by crystal structures of yeast Puf4p | Supplementary information
Reciprocal regulation of the Ca2+ and H+ sensitivity in the SLO1 BK channel conferred by the RCK1 domain - pp403 - 410
Shangwei Hou, Rong Xu, Stefan H Heinemann & Toshinori Hoshi
doi:10.1038/nsmb.1398
Abstract - | Full Text - Reciprocal regulation of the Ca2+ and H+ sensitivity in the SLO1 BK channel conferred by the RCK1 domain | PDF (2,099 KB) - Reciprocal regulation of the Ca2+ and H+ sensitivity in the SLO1 BK channel conferred by the RCK1 domain | Supplementary information
MukB acts as a macromolecular clamp in DNA condensation - pp411 - 418
Yuanbo Cui, Zoya M Petrushenko & Valentin V Rybenkov
doi:10.1038/nsmb.1410
Abstract - | Full Text - MukB acts as a macromolecular clamp in DNA condensation | PDF (665 KB) - MukB acts as a macromolecular clamp in DNA condensation | Supplementary information
Brief Communications
The ARID domain of the H3K4 demethylase RBP2 binds to a DNA CCGCCC motif - pp419 - 421
Shengjiang Tu, Yu-Ching Teng, Chunhua Yuan, Ying-Ta Wu, Meng-Yu Chan, An-Ning Cheng, Po-Hsun Lin, Li-Jung Juan & Ming-Daw Tsai
doi:10.1038/nsmb.1400
PDB code
3D view
Abstract - | Full Text - The ARID domain of the H3K4 demethylase RBP2 binds to a DNA CCGCCC motif | PDF (457 KB) - The ARID domain of the H3K4 demethylase RBP2 binds to a DNA CCGCCC motif | Supplementary information
Crystal structures of two human vitronectin, urokinase and urokinase receptor complexes - pp422 - 423
Qing Huai, Aiwu Zhou, Lin Lin, Andrew P Mazar, Graham C Parry, Jennifer Callahan, David E Shaw, Bruce Furie, Barbara C Furie & Mingdong Huang
doi:10.1038/nsmb.1404
Abstract - | Full Text - Crystal structures of two human vitronectin, urokinase and urokinase receptor complexes | PDF (331 KB) - Crystal structures of two human vitronectin, urokinase and urokinase receptor complexes | Supplementary information
