News and Views
Nature Structural & Molecular Biology 15, 334 - 336 (2008)
doi:10.1038/nsmb0408-334
Think you know how miRNAs work? Think again.
Joel D Richter1
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Joel D. Richter is at the Program in Molecular Medicine, University of Massachusetts Medical School, Biotech 2, Suite 204, 373 Plantation Street, Worcester, Massachusetts 01605, USA.
e-mail: joel.richter@umassmed.edu
Abstract
Two proposed mechanisms for how microRNAs (miRNAs) and their associated Argonaute proteins inhibit translation in mammals do not seem to operate in Drosophila melanogaster cells, suggesting that insights into important miRNA functions remain elusive. However, the interaction between Argonaute and the P-body factor GW182 may help in elucidating the biochemical basis of translational control by miRNAs.
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