News and Views
Nature Structural & Molecular Biology 15, 332 - 334 (2008)
doi:10.1038/nsmb0408-332
INO80 meets a fork in the road
Kelly M Trujillo1 & Mary Ann Osley1
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Kelly M. Trujillo and Mary Ann Osley are in the Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131, USA.
e-mail: mosley@salud.unm.edu
Abstract
The INO80 chromatin-remodeling complex has roles in transcription, DNA repair and replication. By studying the role of Ino80 in DNA replication, a study now finds that the INO80 complex is essential for replication fork progression under conditions of replicative stress, stabilizes stalled forks and helps ensure proper restart.
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