Brief Communication abstract
Nature Structural & Molecular Biology 15, 422 - 423 (2008)
Published online: 23 March 2008 | doi:10.1038/nsmb.1404
Crystal structures of two human vitronectin, urokinase and urokinase receptor complexes
Qing Huai1, Aiwu Zhou2, Lin Lin1, Andrew P Mazar3, Graham C Parry3, Jennifer Callahan3, David E Shaw4, Bruce Furie1, Barbara C Furie1 & Mingdong Huang1
The urokinase receptor (uPAR) can recognize several ligands. The structural basis for this multiple ligand recognition by uPAR is unknown. This study reports the crystal structures of uPAR in complex with both urokinase (uPA) and vitronectin and reveal that uPA occupies the central cavity of the receptor, whereas vitronectin binds at the outer side of the receptor. These results provide a structural understanding of one receptor binding to two ligands.
- Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA.
- Department of Haematology, University of Cambridge, Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, Hills Road, Cambridge CB2 2XY, UK.
- Attenuon, LLC, 11535 Sorrento Valley Rd, Suite 401, San Diego, California 92121, USA.
- D.E. Shaw Research and Development, 39th Floor, Tower 45, 120 West Forty-Fifth Street, New York, New York 10036, USA.
Correspondence to: Mingdong Huang1 e-mail: mhuang1@bidmc.harvard.edu
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