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March 2008 Volume 15 No 3

The eukaryotic proteasome catalyzes the selective degradation of targeted proteins. New structural and functional work reveals the role of a chaperone complex in directing assembly of the proteasome core, or 20S, particle. Cover by Erin Boyle shows the 20S proteasome with the chaperone complex, in the style of artist Mark Rothko. pp 228 and 237, News and Views p 218

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