News and Views
Nature Structural & Molecular Biology 15, 221 - 222 (2008)
doi:10.1038/nsmb0308-221
Ankyrin for methylated lysines
Michael M Brent1 & Ronen Marmorstein1
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Michael M. Brent and Ronen Marmorstein are at the Wistar Institute and the Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
e-mail: marmor@wistar.org
Abstract
The ankyrin repeats of the G9a and GLP histone methyltransferases have now been shown to be binding modules for mono- and dimethyllysine histone H3 lysine 9 (H3K9), revealing a new function for an ankyrin repeat domain and showing that a polypeptide chain can both create and recognize the same histone mark.
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