News and Views


Nature Structural & Molecular Biology 15, 221 - 222 (2008)
doi:10.1038/nsmb0308-221

Ankyrin for methylated lysines

Michael M Brent1 & Ronen Marmorstein1

  1. Michael M. Brent and Ronen Marmorstein are at the Wistar Institute and the Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
    e-mail: marmor@wistar.org


The ankyrin repeats of the G9a and GLP histone methyltransferases have now been shown to be binding modules for mono- and dimethyllysine histone H3 lysine 9 (H3K9), revealing a new function for an ankyrin repeat domain and showing that a polypeptide chain can both create and recognize the same histone mark.

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