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Nature Structural & Molecular Biology 15, 1238–1240 (1 December 2008) | doi:10.1038/nsmb1208-1238
The N-end rule at atomic resolution
Abstract
The discovery, through studies carried out between 1984 and 1990, of the biological fundamentals of the ubiquitin system and its remarkable functional reach (reviewed in refs. 1,2) gave rise to a new understanding in which regulated intracellular proteolysis became a central feature of cellular physiology.
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