News and Views
Nature Structural & Molecular Biology 15, 1241 - 1242 (2008)
doi:10.1038/nsmb1208-1241
When loose ends finally meet
Michael S Y Huen1 & Junjie Chen1
-
Michael S.Y. Huen and Junjie Chen are in the Department of Therapeutic Radiology, Yale University School of Medicine, 333 Cedar Street, PO Box 208040, New Haven, Connecticut 06520, USA.
e-mail: junjie.chen@yale.edu
Abstract
The tumor suppressor protein 53BP1 decorates DNA damage sites and is instrumental for nonhomologous end joining. Evidence that 53BP1 facilitates synapsis of DNA ends by modulating chromatin dynamics reveals a hitherto unanticipated strategy for joining distant ends.
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
NEWS AND VIEWS
Paradigm switching in the germinal centerNature Immunology News and Views (01 May 2004)
Class switching and Myc translocation: how does DNA break?Nature Immunology News and Views (01 Nov 2004)
RESEARCH
Conditional deletion of Nbs1 in murine cells reveals its role in branching repair pathways of DNA double-strand breaksThe EMBO Journal Article (29 Nov 2006)
53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobilityNature Letters to Editor (27 Nov 2008)
See all 10 matches for Research
