News and Views
Nature Structural & Molecular Biology 15, 1238 - 1240 (2008)
doi:10.1038/nsmb1208-1238
The N-end rule at atomic resolution
Alexander Varshavsky1
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Alexander Varshavsky is in the Division of Biology, California Institute of Technology, Pasadena, California 91125, USA.
e-mail: avarsh@caltech.edu
Abstract
The N-end rule relates the in vivo half-life of a protein to the identity of its N-terminal residue. The N-end rule pathway, ubiquitin-dependent in eukaryotes, is also present in prokaryotes, which lack the ubiquitin system. An illuminating new study presents the crystal structure of a bacterial N-end rule recognition component in complex with a peptide containing a cognate degradation signal.
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