Access
To read this article in full you may need to log in, make a payment or gain access through a site license (see right).
News and Views
Nature Structural & Molecular Biology 15, 1133–1134 (1 November 2008) | doi:10.1038/nsmb1108-1133
An INKlination for epigenetic control of senescence
Abstract
Dynamic post-translational modification of histones is central to the regulation of gene expression and other aspects of chromatin biology. A striking example is the potential role of the H3K27me3 modification (trimethylation of histone H3 on lysine 27) and Polycomb group (PcG) proteins in the maintenance of pluripotency and more specifically in repression of the Ink4a-Arf tumor-suppressor locus.
To read this article in full you may need to log in, make a payment or gain access through a site license (see right).
