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Brief Communication

Nature Structural & Molecular Biology 15, 1221–1222 (1 November 2008) | doi:10.1038/nsmb.1509

Structural basis for exon recognition by a group II intron

Navtej Toor , Kanagalaghatta Rajashankar , Kevin S Keating & Anna Marie Pyle

Free group II introns are infectious retroelements that can bind and insert themselves into RNA and DNA molecules via reverse splicing. Here we report the 3.4-|[Aring]| crystal structure of a complex between an oligonucleotide target substrate and a group IIC intron, as well as the refined free intron structure.