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Nature Structural & Molecular Biology 15, 1133 - 1134 (2008)
doi:10.1038/nsmb1108-1133
An INKlination for epigenetic control of senescence
Gordon Peters1
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Gordon Peters is at Cancer Research UK, London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3PX, UK.
e-mail: gordon.peters@cancer.org.uk
Abstract
Much has been written and said about the links between the Ink4a-Arf locus, cellular senescence and stem-cell maintenance. Standing modestly in the shadows of these superstars of tumor suppression, the closely linked Ink4b gene is now emerging as a significant player in these events, and its regulation by a histone demethylase could provide new insights into how this remarkable locus is controlled.
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