Brief Communication abstract
Nature Structural & Molecular Biology 15, 1221 - 1222 (2008)
Published online: 26 October 2008 | doi:10.1038/nsmb.1509
Structural basis for exon recognition by a group II intron
Navtej Toor1,2, Kanagalaghatta Rajashankar3, Kevin S Keating4 & Anna Marie Pyle1,2
Free group II introns are infectious retroelements that can bind and insert themselves into RNA and DNA molecules via reverse splicing. Here we report the 3.4-Å crystal structure of a complex between an oligonucleotide target substrate and a group IIC intron, as well as the refined free intron structure. The structure of the complex reveals the conformation of motifs involved in exon recognition by group II introns.
- Department of Molecular Biophysics and Biochemistry, Yale University, 266 Whitney Avenue, New Haven, Connecticut 06520, USA.
- Howard Hughes Medical Institute, Yale University, 266 Whitney Avenue, New Haven, Connecticut 06520, USA.
- The Northeastern Collaborative Access Team (NE-CAT) at the Advanced Photon Source at Argonne National Laboratory, 9700 South Cass Avenue, Argonne, Illinois 60439, USA.
- Program in Computational Biology and Bioinformatics, Yale University, 266 Whitney Avenue, New Haven, Connecticut 06511, USA.
Correspondence to: Anna Marie Pyle1,2 e-mail: anna.pyle@yale.edu
Correspondence to: Kanagalaghatta Rajashankar3 e-mail: rajashankar@anl.gov
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