1. Aziz Sancar is in the Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA. e-mail: aziz_sancar@med.unc.edu

Abstract

Circadian rhythms are generated by cell-autonomous molecular clocks in organisms ranging from cyanobacteria to humans. Recent research on the mechanisms of molecular clocks call for a reflection on the cause and necessity of complexity in biological systems.

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