News and Views
Nature Structural & Molecular Biology 15, 20 - 22 (2008)
doi:10.1038/nsmb0108-20
DNA damage: ubiquitin marks the spot
Eric J Bennett1 & J Wade Harper1
- Eric J. Bennett and J. Wade Harper are at the Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA. e-mail: wade_harper@hms.harvard.edu
Abstract
DNA damage activates signaling cascades driven by the ATM–ATR protein kinases, culminating in the recruitment of repair proteins to the damage site through poorly understood mechanisms. Now a flurry of papers reveals how ATM-dependent phosphorylation of mediator and chromatin-associated proteins at sites of double-strand breaks promotes ubiquitylation of local nucleosomes, thereby eliciting a powerful signal for recruitment of repair complexes to the damage site.
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