News and Views
Nature Structural & Molecular Biology 14, 792 - 794 (2007)
doi:10.1038/nsmb0907-792
Chloride finds its place in the transport cycle
Susan G Amara1
- Susan G. Amara is at the Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA. e-mail: amaras@pitt.edu
Abstract
Neurotransmitter:sodium symporters, which use sodium gradients for the coupled uptake of sodium and neurotransmitters during synaptic transmission, often display a chloride dependence. New data from two separate groups identify the chloride-binding site for this family of symporters and suggest that the chloride charge facilitates sodium binding and substrate transport.
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