Article abstract
Nature Structural & Molecular Biology 14, 710 - 715 (2007)
Published online: 22 July 2007 | doi:10.1038/nsmb1277
CCDC98 is a BRCA1-BRCT domain–binding protein involved in the DNA damage response
Hongtae Kim1,2, Jun Huang1,2 & Junjie Chen1
Abstract
The product of the breast cancer-1 gene, BRCA1, plays a crucial part in the DNA damage response through its interactions with many proteins, including BACH1, CtIP and RAP80. Here we identify a coiled-coil domain–containing protein, CCDC98, as a BRCA1-interacting protein. CCDC98 colocalizes with BRCA1 and is required for the formation of BRCA1 foci in response to ionizing radiation. Moreover, like BRCA1, CCDC98 has a role in radiation sensitivity and damage-induced G2/M checkpoint control. Together, these results suggest that CCDC98 is a mediator of BRCA1 function involved in the mammalian DNA damage response.
- Department of Therapeutic Radiology, Yale University School of Medicine, P.O. Box 208040, New Haven, Connecticut 06520, USA.
- These authors contributed equally to this work.
Correspondence to: Junjie Chen1 e-mail: junjie.chen@yale.edu
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