News and Views
Nature Structural & Molecular Biology 14, 686 - 687 (2007)
doi:10.1038/nsmb0807-686
Finding the right spot to start transcription
Patrick Cramer1
- Patrick Cramer is at the Gene Center Munich and the Center for Integrated Protein Science (CiPSM), Department of Chemistry and Biochemistry, Ludwig-Maximilians-Universität München, Feodor-Lynen-Strasse 25, 81377 Munich, Germany. e-mail: cramer@lmb.uni-muenchen.de
Abstract
How does RNA polymerase II cooperate with initiation factors to locate transcription start sites throughout the genome? A new cross-linking approach reveals previously unknown initiation factor–binding sites on the polymerase surface. The resulting model of the transcription initiation complex suggests that initiation factors cooperate above and inside the polymerase active center cleft to open DNA and find the transcription start site.
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
NEWS AND VIEWS
The Pol II initiation complex: finding a place to startNature Structural & Molecular Biology News and Views (01 Jul 2006)
Simplifying the complexNature News and Views (31 Mar 1994)
See all 8 matches for News And ViewsRESEARCH
The positions of TFIIF and TFIIE in the RNA polymerase II transcription preinitiation complexNature Structural & Molecular Biology Article (01 Aug 2007)
A DNA-tethered cleavage probe reveals the path for promoter DNA in the yeast preinitiation complexNature Structural & Molecular Biology Article (01 Jul 2006)
See all 43 matches for Research
