A timely reminder - p569

doi:10.1038/nsmb0707-569

Full Text - A timely reminder | PDF (76 KB) - A timely reminder

A SUMO ligase for ALT - pp570 - 571

Roger R Reddel

doi:10.1038/nsmb0707-570

Full Text - A SUMO ligase for ALT | PDF (469 KB) - A SUMO ligase for ALT

See also: Article by Potts & Yu

Not miR-ly a splicing factor: hnRNP A1 succumbs to microRNA temptation - pp572 - 573

Anne Færch Nielsen, Philipp J F Leuschner & Javier Martinez

doi:10.1038/nsmb0707-572

Full Text - Not miR-ly a splicing factor: hnRNP A1 succumbs to microRNA temptation | PDF (245 KB) - Not miR-ly a splicing factor: hnRNP A1 succumbs to microRNA temptation

See also: Article by Guil & Cáceres

Powering a two-stroke RNA engine - pp574 - 576

Josep Vilardell & Juan Valcárcel

doi:10.1038/nsmb0707-574

Full Text - Powering a two-stroke RNA engine | PDF (235 KB) - Powering a two-stroke RNA engine

See also: Article by Shen & Green

RNA-binding proteins switch gears to drive alternative splicing in neurons - pp577 - 579

Paula J Grabowski

doi:10.1038/nsmb0707-577

Full Text - RNA-binding proteins switch gears to drive alternative splicing in neurons | PDF (331 KB) - RNA-binding proteins switch gears to drive alternative splicing in neurons

An ESCRT for daughters - p579

Michelle Montoya

doi:10.1038/nsmb0707-579

Full Text - An ESCRT for daughters | PDF (125 KB) - An ESCRT for daughters

Research highlights - p580

doi:10.1038/nsmb0707-580

Full Text - Research highlights | PDF (68 KB) - Research highlights

The SMC5/6 complex maintains telomere length in ALT cancer cells through SUMOylation of telomere-binding proteins - pp581 - 590

Patrick Ryan Potts & Hongtao Yu

doi:10.1038/nsmb1259

Abstract - The SMC5/6 complex maintains telomere length in ALT cancer cells through SUMOylation of telomere-binding proteins | Full Text - The SMC5/6 complex maintains telomere length in ALT cancer cells through SUMOylation of telomere-binding proteins | PDF (524 KB) - The SMC5/6 complex maintains telomere length in ALT cancer cells through SUMOylation of telomere-binding proteins | Supplementary information

See also: News and Views by Reddel

The multifunctional RNA-binding protein hnRNP A1 is required for processing of miR-18a - pp591 - 596

Sonia Guil & Javier F Cáceres

doi:10.1038/nsmb1250

Abstract - The multifunctional RNA-binding protein hnRNP A1 is required for processing of miR-18a | Full Text - The multifunctional RNA-binding protein hnRNP A1 is required for processing of miR-18a | PDF (307 KB) - The multifunctional RNA-binding protein hnRNP A1 is required for processing of miR-18a | Supplementary information

See also: News and Views by Nielsen et al.

RS domain–splicing signal interactions in splicing of U12-type and U2-type introns - pp597 - 603

Haihong Shen & Michael R Green

doi:10.1038/nsmb1263

Abstract - RS domain-splicing signal interactions in splicing of U12-type and U2-type introns | Full Text - RS domain–splicing signal interactions in splicing of U12-type and U2-type introns | PDF (396 KB) - RS domain–splicing signal interactions in splicing of U12-type and U2-type introns | Supplementary information

See also: News and Views by Vilardell & Valcárcel

Physical and functional coupling of RNA-dependent RNA polymerase and Dicer in the biogenesis of endogenous siRNAs - pp604 - 610

Suzanne R Lee & Kathleen Collins

doi:10.1038/nsmb1262

Abstract - Physical and functional coupling of RNA-dependent RNA polymerase and Dicer in the biogenesis of endogenous siRNAs | Full Text - Physical and functional coupling of RNA-dependent RNA polymerase and Dicer in the biogenesis of endogenous siRNAs | PDF (337 KB) - Physical and functional coupling of RNA-dependent RNA polymerase and Dicer in the biogenesis of endogenous siRNAs | Supplementary information

Holoenzyme assembly and ATP-mediated conformational dynamics of topoisomerase VI - pp611 - 619

Kevin D Corbett, Piero Benedetti & James M Berger

doi:10.1038/nsmb1264

Abstract - Holoenzyme assembly and ATP-mediated conformational dynamics of topoisomerase VI | Full Text - Holoenzyme assembly and ATP-mediated conformational dynamics of topoisomerase VI | PDF (706 KB) - Holoenzyme assembly and ATP-mediated conformational dynamics of topoisomerase VI | Supplementary information

U2AF-homology motif interactions are required for alternative splicing regulation by SPF45 - pp620 - 629

Lorenzo Corsini, Sophie Bonnal, Jerome Basquin, Michael Hothorn, Klaus Scheffzek, Juan Valcárcel & Michael Sattler

doi:10.1038/nsmb1260

• PDB code

  • 2PE8
  • 2PEH

• 3D view

  • 2PE8
  • 2PEH

Abstract - U2AF-homology motif interactions are required for alternative splicing regulation by SPF45 | Full Text - U2AF-homology motif interactions are required for alternative splicing regulation by SPF45 | PDF (700 KB) - U2AF-homology motif interactions are required for alternative splicing regulation by SPF45 | Supplementary information

Alternative splicing regulation by interaction of phosphatase PP2C with nucleic acid–binding protein YB-1 - pp630 - 638

Eric Allemand, Michelle L Hastings, Michael V Murray, Michael P Myers & Adrian R Krainer

doi:10.1038/nsmb1257

Abstract - Alternative splicing regulation by interaction of phosphatase PP2C: [gamma]: with nucleic acid-binding protein YB-1 | Full Text - Alternative splicing regulation by interaction of phosphatase PP2C with nucleic acid–binding protein YB-1 | PDF (372 KB) - Alternative splicing regulation by interaction of phosphatase PP2C with nucleic acid–binding protein YB-1 | Supplementary information

Role of Dnl4–Lif1 in nonhomologous end-joining repair complex assembly and suppression of homologous recombination - pp639 - 646

Yu Zhang, Melissa L Hefferin, Ling Chen, Eun Yong Shim, Hui-Min Tseng, Youngho Kwon, Patrick Sung, Sang Eun Lee & Alan E Tomkinson

doi:10.1038/nsmb1261

Abstract - Role of Dnl4-Lif1 in nonhomologous end-joining repair complex assembly and suppression of homologous recombination | Full Text - Role of Dnl4–Lif1 in nonhomologous end-joining repair complex assembly and suppression of homologous recombination | PDF (445 KB) - Role of Dnl4–Lif1 in nonhomologous end-joining repair complex assembly and suppression of homologous recombination | Supplementary information

Structural basis for DNA duplex separation by a superfamily-2 helicase - pp647 - 652

Katharina Büttner, Sebastian Nehring & Karl-Peter Hopfner

doi:10.1038/nsmb1246

• PDB code

  • 2P6U
  • 2P6R

• 3D view

  • 2P6U
  • 2P6R

Abstract - Structural basis for DNA duplex separation by a superfamily-2 helicase | Full Text - Structural basis for DNA duplex separation by a superfamily-2 helicase | PDF (535 KB) - Structural basis for DNA duplex separation by a superfamily-2 helicase | Supplementary information

A TAF4-homology domain from the corepressor ETO is a docking platform for positive and negative regulators of transcription - pp653 - 661

Yufeng Wei, Shaohua Liu, Jörn Lausen, Christopher Woodrell, Seongeun Cho, Nikolaos Biris, Naohiro Kobayashi, Yu Wei, Shigeyuki Yokoyama & Milton H Werner

doi:10.1038/nsmb1258

• PDB code

  • 2PP4

• 3D view

  • 2PP4

Abstract - A TAF4-homology domain from the corepressor ETO is a docking platform for positive and negative regulators of transcription | Full Text - A TAF4-homology domain from the corepressor ETO is a docking platform for positive and negative regulators of transcription | PDF (654 KB) - A TAF4-homology domain from the corepressor ETO is a docking platform for positive and negative regulators of transcription | Supplementary information

The poly(A)-dependent transcriptional pause is mediated by CPSF acting on the body of the polymerase - pp662 - 669

Anita Nag, Kazim Narsinh & Harold G Martinson

doi:10.1038/nsmb1253

Abstract - The poly(A)-dependent transcriptional pause is mediated by CPSF acting on the body of the polymerase | Full Text - The poly(A)-dependent transcriptional pause is mediated by CPSF acting on the body of the polymerase | PDF (318 KB) - The poly(A)-dependent transcriptional pause is mediated by CPSF acting on the body of the polymerase | Supplementary information

A cell type–restricted mRNA surveillance pathway triggered by ribosome extension into the 3' untranslated region - pp670 - 676

Jian Kong & Stephen A Liebhaber

doi:10.1038/nsmb1256

Abstract - A cell type-restricted mRNA surveillance pathway triggered by ribosome extension into the 3[prime] untranslated region | Full Text - A cell type–restricted mRNA surveillance pathway triggered by ribosome extension into the 3' untranslated region | PDF (338 KB) - A cell type–restricted mRNA surveillance pathway triggered by ribosome extension into the 3' untranslated region | Supplementary information

Role for BLM in replication-fork restart and suppression of origin firing after replicative stress - pp677 - 679

Sally L Davies, Phillip S North & Ian D Hickson

doi:10.1038/nsmb1267

Abstract - Role for BLM in replication-fork restart and suppression of origin firing after replicative stress | Full Text - Role for BLM in replication-fork restart and suppression of origin firing after replicative stress | PDF (170 KB) - Role for BLM in replication-fork restart and suppression of origin firing after replicative stress | Supplementary information

Corrigendum: Interaction with the BRCA2 C terminus protects RAD51–DNA filaments from disassembly by BRC repeats - p680

Owen R Davies & Luca Pellegrini

doi:10.1038/nsmb0707-680a

Full Text - Corrigendum: Interaction with the BRCA2 C terminus protects RAD51–DNA filaments from disassembly by BRC repeats | PDF (50 KB) - Corrigendum: Interaction with the BRCA2 C terminus protects RAD51–DNA filaments from disassembly by BRC repeats

Corrigendum: Structural insight into the substrate specificity of DNA Polymerase - p680

Andrea F Moon, Miguel Garcia-Diaz, Katarzyna Bebenek, Bryan J Davis, Xuejun Zhong, Dale A Ramsden, Thomas A Kunkel & Lars C Pedersen

doi:10.1038/nsmb0707-680b

Full Text - Corrigendum: Structural insight into the substrate specificity of DNA Polymerase | PDF (50 KB) - Corrigendum: Structural insight into the substrate specificity of DNA Polymerase