News and Views
Nature Structural & Molecular Biology 14, 577 - 579 (2007)
doi:10.1038/nsmb0707-577
RNA-binding proteins switch gears to drive alternative splicing in neurons
Paula J Grabowski1
-
Paula J. Grabowski is in the Department of Biological Sciences, University of Pittsburgh, 4249 Fifth Avenue, Pittsburgh, Pennsylvania 15221, USA.
e-mail: pag4@pitt.edu
Abstract
A new study reveals that cells naturally switch from expressing one polypyrimidine tract–binding protein (PTB) to a highly similar family member, nPTB, during the development of neurons, and shows that PTB itself regulates this transition. Ensembles of coregulated exons simultaneously change their splicing patterns, suggesting that this phenomenon could potentially mediate widespread changes in proteins composed of modular functional domains, thus driving neuronal phenotypes or disfavoring non-neuronal ones.
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
RESEARCH
The PTB interacting protein raver1 regulates α-tropomyosin alternative splicingThe EMBO Journal Article (01 Dec 2003)
The PTB interacting protein raver1 regulates α-tropomyosin alternative splicingThe EMBO Journal Article (01 Dec 2003)
See all 4 matches for Research
