News and Views
Nature Structural & Molecular Biology 14, 572 - 573 (2007)
doi:10.1038/nsmb0707-572
Not miR-ly a splicing factor: hnRNP A1 succumbs to microRNA temptation
Anne Færch Nielsen1, Philipp J F Leuschner2 & Javier Martinez2
- Anne Færch Nielsen is in the Department of Molecular Biology, University of Aarhus, CF Møllers Allé 1130, 8000 Aarhus C, Denmark
-
Philipp J. F. Leuschner and Javier Martinez are at the Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr.-Bohr-Gasse 3, 1030, Vienna, Austria.
e-mail: javier.martinez@imba.oeaw.ac.at
Abstract
MicroRNAs are small, noncoding RNAs that regulate gene expression in eukaryotes. The multipurpose protein hnRNP A1, a well-known factor in the regulation of precursor messenger RNA splicing, has now been implicated in the biogenesis of the microRNA miR-18a, shedding further light on the emerging topic of post-transcriptional regulation of microRNA expression.
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