1. David M. Roberts, Kevin C. Slep and Mark Peifer are in the Department of Biology, and David M. Roberts and Mark Peifer are at the Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, CB#3280, Coker Hall, Chapel Hill, North Carolina 27599–3280, USA. e-mail: peifer@unc.edu

Abstract

Wnt signaling has key roles in embryogenesis and oncogenesis, yet several aspects of Wnt signal transduction remain mysterious. Schwarz-Romond et al. demonstrate that the Wnt signaling protein Dishevelled has the surprising ability to form dynamic polymers and present evidence that polymerization is crucial in signaling, perhaps forming an inducible scaffold for further signal transduction.

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