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Brief Communication

Nature Structural & Molecular Biology 14, 344–346 (1 April 2007) | doi:10.1038/nsmb1217

The trithorax-group gene in Drosophila little imaginal discs encodes a trimethylated histone H3 Lys4 demethylase

Joel C Eissenberg , Min Gyu Lee , Jessica Schneider , Anne Ilvarsonn , Ramin Shiekhattar & Ali Shilatifard

Histone H3 Lys4 (H3K4) is methylated by yeast Set1–COMPASS and its mammalian homolog, the MLL complex. Human JARID1d can demethylate trimethyl-H3K4 (H3K4me3).