About the cover

April 2007 Volume 14 No 4

Two GAD isoforms are responsible for GABA synthesis. Whisstock and colleagues solve the structure of the GAD isoforms, finding that a tethered loop in the constitutively active GAD67 is mobile in GAD65 and involved in its auto-activation. The pair of leaves represents the GAD dimer with the curled edge reminiscent of the catalytic loop that protects the active site in GAD67.
Artwork by Pascal Ouellet
(www.bigoudi.ca).
pp 280-286


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