About the cover

April 2007 Volume 14 No 4

Two GAD isoforms are responsible for GABA synthesis. Whisstock and colleagues solve the structure of the GAD isoforms, finding that a tethered loop in the constitutively active GAD67 is mobile in GAD65 and involved in its auto-activation. The pair of leaves represents the GAD dimer with the curled edge reminiscent of the catalytic loop that protects the active site in GAD67.
Artwork by Pascal Ouellet
pp 280-286

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