Brief Communication abstract
Nature Structural & Molecular Biology 14, 349 - 350 (2007)
Published online: 25 March 2007 | doi:10.1038/nsmb1220
The 3' termini of mouse Piwi-interacting RNAs are 2'-O-methylated
Tomoya Ohara1, Yuriko Sakaguchi1, Takeo Suzuki1, Hiroki Ueda1,2, Kenjyo Miyauchi1,2 & Tsutomu Suzuki1
Piwi-interacting RNAs (piRNAs) are a germline-specific class of small noncoding RNAs that are essential for spermatogenesis, but their function and biogenesis remain elusive. Here we report a post-transcriptional modification of mouse piRNAs. Mass spectrometric analysis reveals that the piRNAs tested are fully modified by 2'-O-methylation at their 3' termini. This observation may provide a clue to the biogenesis and function of piRNAs in spermatogenesis.
- Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
- Japan Biological Informatics Consortium, TIME 24 BLDG. 10F, 2-45 Aomi, Koto-ku, Tokyo, 135-0064, Japan.
Correspondence to: Tsutomu Suzuki1 e-mail: ts@chembio.t.u-tokyo.ac.jp
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