1. N. Patrick Higgins is in the Department of Biochemistry and Molecular Genetics, University of Alabama, Birmingham, Alabama 35294-0024, USA. e-mail: nphiggin@uab.edu

Abstract

In this issue, Nöllmann and colleagues report single-molecule analyses of DNA gyrase action on supercoiled DNA under different levels of strain. Surprisingly, they found that gyrase changes its reaction mechanism in response to changes in DNA strain. This explains the role of ATP in a branching topoisomerase reaction pathway and revisits an old puzzle about gyrase reversibility.

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