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Brief Communication

Nature Structural & Molecular Biology 14, 243–245 (1 March 2007) | doi:10.1038/nsmb1204

Yeast Jhd2p is a histone H3 Lys4 trimethyl demethylase

Gaoyang Liang , Robert J Klose , Kathryn E Gardner & Yi Zhang

Histone methylation is important in regulating chromatin structure and function. In budding yeast, methylation of histone H3 at Lys4 (H3-K4) is associated with active transcription and is enriched at the 5|[prime]| regions of transcribed genes.