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Brief Communication
Nature Structural & Molecular Biology 14, 240–242 (1 March 2007) | doi:10.1038/nsmb1200
Demethylation of trimethylated histone H3 Lys4 in vivo by JARID1 JmjC proteins
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Abstract
Histone H3 Lys4 trimethylation (H3-K4me3) is a conserved mark of actively transcribed chromatin. Using a conditional mutant of the yeast H3-K4 methyltransferase, Set1p, we demonstrate rapid turnover of H3-K4me3 and H3-K4me2 in vivo and show this process requires Yjr119Cp, of the JARID1 family of JmjC proteins. Ectopic overexpression of mouse Jarid1B, a Yjr119Cp homolog, greatly diminished H3-K4me3 and H3-K4me2 in HeLa cells, suggesting these proteins function as K4 demethylases in vivo.
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